Achievements
- Co-founder of Talc, a Y Combinator S23 startup focused on AI-powered event extraction for medical research
- Built advanced AI tools to help medical researchers analyze complex data sets
- Over 6 years of engineering experience at Facebook and Airbnb
- Worked on Election Integrity at Facebook, developing systems to detect foreign interference campaigns
- Applied deep technical expertise from Facebook and Airbnb to build impactful AI solutions in healthcare research
- Led efforts to debug and test large language models and AI systems at Talc
Big ups to Matt Lee
Respect the hustle of Matt Lee – this dude’s the real deal. So, he’s a YC S23 guy, but his story’s way more than just that. He’s been in the trenches at Facebook, Airbnb, and now he’s crushing it with Talc, a startup he co-founded in Seattle that’s all about helping medical researchers pull out event data from crazy amounts of info. Basically, he’s building AI tools to make sense of medical research – super niche, super needed.
But here’s what’s wild – before jumping into startups, Matt spent over six years at Facebook and Airbnb. At Facebook, he was deep in the Election Integrity game, working on ways to catch foreign interference campaigns. Think about that – he was working on some of the most sensitive, high-stakes tech to protect democracy. That’s some serious shit. It shows he’s got skills in building expandable, tough tech and a nose for problems that matter.
What does this all say about him? Dude’s driven by solving real problems, not just chasing shiny tech for the hell of it. He’s got that hacker mindset but also the hustle to turn ideas into actual products that can change industries. His time at Facebook and Airbnb gave him a legendary technical foundation, and now he’s applying that to AI and machine learning, specifically in the medical research space with Talc. He’s not just building for the sake of it – he’s tackling a niche where AI can actually save lives, or at least make research way more fast.
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Talk to herSo, why is this important? Because Matt’s story is about taking what you learn from giants like Facebook and Airbnb and jumping into startups with a purpose. He’s the kind of guy who’s not afraid to get his hands dirty, who sees big problems and goes after them head-on. Talc isn’t just another YC company – it’s a reflection of his whole vibe: deep tech, real-world impact, and a relentless drive to build stuff that matters. No Cap, he’s just getting started, and he’s one to watch.
Experience
Industries
Sources to check more about Matt Lee
- Episode 17: Matthew Lee- Building a career in Venture Capital ...
- Meet the Seattle-area startups that just graduated from Y Combinator
- Speedscale: Speed up development by simulating production ...
- Talc: Event extraction for Medical Researchers - Y Combinator
- Quit all your excuses. lock in bro Comment “Free” for the guide

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