Beth Hoffman

Beth Hoffman

Y Combinator Logo Batch: W22

Getting real about Beth Hoffman

Here’s some fire content about Beth Hoffman, this dude’s the real deal, and his story is straight-up inspiring. So, Beth’s part of YC’s W22 batch, which means he jumped into the startup game kinda recently but already made some serious waves. Before diving into the startup world, he was grinding at some big pharma and biotech giants, Vertex, Amgen, Eli Lilly, you name it. Basically, the guy’s got mad experience in biotech and pharma, understanding what it takes to innovate in health tech and medicine.

But here’s the kicker: he didn’t stop there. He’s got a background that screams hustle and deep expertise, and he decided to take all that knowledge and turn it into something new. That’s why he’s now the founder of Origami Therapeutics, Inc., a company that’s probably pushing boundaries in biotech, the kind of stuff that could change lives. Starting something in biotech is no joke, it’s long, it’s risky, and the stakes are high. Beth jumped into that world not just to make a quick buck but because he’s genuinely driven by the desire to solve real problems, to push the envelope, and to make a difference.

Looking at his process, what jumps out is that Beth’s all about impact, not just the tech or business side. His pharma background proves he’s a scientist at heart, but his decision to co-found a startup shows he’s got that entrepreneur’s fire. He’s the type who crushed it in corporate, yet he saw bigger possible in going all-in on his own thing. That’s what makes him stand out. He’s not just riding on past success; he’s actively shaping the future.

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And honestly, his story is a blueprint for anyone who’s been in the trenches of big corporations but wants to go all-in on their own vision. It’s about the courage to jump in, to take what you’ve learned, and to create something that’s totally your own. Beth Hoffman? He’s that guy who’s proof that if you’ve got the experience, the passion, and the guts, you can really make an impact. No Cap, he’s the real deal in biotech and startups, and I’m hyped to see where he takes this next.

Founder ID: 103321

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