Achievements
- Co-founded Signatur Biosciences in 2022, a Y Combinator S22 biotech startup
- Developing smart PCR kits to make DNA testing faster, cheaper, and more accessible for breast cancer prognosis
- Pioneering the use of machine learning to teach molecules and expand PCR diagnostic capabilities, calling himself a 'PCRchitect'
- Holds a PhD in Bioengineering from the University of Maryland and a BSc in Physics and Cell & Molecular Biology from Seattle University
- Completed NIH F32 Postdoctoral Fellowship at Imperial College London in the Stevens Group
- Signatur Biosciences is based in San Francisco and London, aiming to revolutionize molecular diagnostics
The story of John Goertz
We’re about to simp for John Goertz. This guy’s the real deal in biotech startup land. He’s a YC S22 alum, so he’s been through the grind, and he’s crushing it with his company, Signatur Biosciences. Basically, they’re all about making DNA testing smarter and way more accessible, starting with breast cancer prognosis. Think about it – instead of waiting weeks for results or paying a ton, they’re building these tiny, smart PCR kits you can run right in local hospitals. Game changer, no Cap.
Now, who is John? He’s a total nerd in the best way. He calls himself a ‘PCRchitect’ – that’s him teaching machines how to understand molecules better, pushing PCR tech to diagnose way more diseases. Dude’s not just some scientist – he’s a builder who wants to make diagnostics faster, cheaper, and more precise. That’s his mission, and he’s all in.
His background? Crazy impressive. He’s got a PhD in Bioengineering from Maryland and a BSc in Physics and Cell & Molecular Bio from Seattle U. Plus, he did a postdoc at Imperial College London on an NIH fellowship – so, the guy’s legit, super smart, and has international creds. But what really stands out is his motivation. He’s not just doing this for the science – he wants to change how medicine works, make it better for everyone. That drive is what led him to co-found Signatur in 2022, with bases in SF and London, aiming to shake up the diagnostics game.
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Talk to herOutside of all that science hustle, he’s into cooking, running, and practicing Japanese Jujitsu – he’s a well-rounded dude who’s into discipline and pushing himself. But his real passion? Building stuff that matters, solving big health problems, and making a real impact. His process from academia to founding a biotech startup shows he’s not afraid to jump into the unknown, take risks, and go all-in on ideas that can save lives.
Bottom line? John Goertz is a scientist turned startup founder who’s not just dreaming about the future of medicine – he’s building it. The dude’s all about making complex diseases diagnosable in a fraction of the time and cost, and he’s got the skills, background, and grit to actually pull it off. No bullshit, he’s the type of guy who’s gonna change the game.

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